Endocrine Abstracts

Introduction: Hepatic metabolism of inhaled corticosteroids (ICS) takes place via cytochrome P450 3A4. Nevertheless, it can be decreased by enzyme inhibitors such as itraconazole or ritonavir, thus leading to an increase in the bioavailability of ICS. This can result in an accumulation of the steroid drug and a cushing’s syndrome.Case report: We present the case of a 48 year old woman with human immunodeficiency virus (HIV) infection on highly activ...

Case 1: 78-years-old female with progressive increase volume in cervical area with dysphagia, drowsiness, slowness, dispnea, and change in of voice. Hypothyroidism and a TPO >1000 UI/ml. Thyroid ultrasound: heterogeneous mass in the left lobe, vascularized with ipsilateral multiple lymph nodes of 0.8×0.6 cm. PAAF: Bethesda 1. Four weeks later course with major obstruction of the upper airway. In ER a near-total thyroidectomy is performed. Postoperatory without complic...

Introduction: During pregnancy, the thyroid volume (TV) increases by 20% to 35% in areas with iodine deficiency. In iodine-sufficient countries, while some studies showed an increase in TV by 10–15%, others did not observe any change in TV during pregnancy. Thyroid nodules may be present in up to 15–35% of pregnant women in areas with moderate iodine deficiency. However, in areas with iodine-sufficient, thyroid nodules were investigated in a few number of studies...

Introduction: The changes observed in thyroid ultrasound during pregnancy are related to the nutritional status of iodine, but its association with TSH levels or the presence of thyroid peroxidase antibodies (TPOAb) is unclear.Objective: To compare the relationship between the findings in thyroid ultrasound and thyroid function tests in the first trimester of pregnancy in an iodine sufficient area.Subjects and methods: We conducted...

Objectives: Diabetes and obesity – Translational cardiovascular and obesityData regarding the prevalence of eating disorders (ED) and their influence on clinical outcomes among patients with type 2 diabetes (T2DM) are scarce. Our aim is to investigate the frequency of positive screening for ED and, specifically binge eating disorder (BED), in a T2DM sample. To analyse whether there are any differences among T2DM subjects with a positive screening for ED or BED.<p clas...

Objective: We investigated the clinical usefulness of thyroid blood flow measurement by colour-flow Doppler ultrasonography in predicting relapse of Graves’ disease (GD).Patients and methods: In 30 euthyroid GD patients, (eight males and 23 females), aged 17–68 years (mean 43.8±12.8), after at least 1 year of treatment with anti-thyroid drug (ATD) and just before its withdrawal, we evaluate with colour-flow Doppler ultrasonography the colo...

Thyroid cancer is one of the endocrine pathologies whose incidence is increasing, although in general terms it has a good outcome. However, some patients develop aggressive forms that are untreatable and the molecular basis is poorly understood. These aggressive forms are basically well-differentiated thyroid carcinomas that undergo dedifferentiation and poorly differentiated and anaplastic carcinomas. All of them have lost Na/I Symporter (NIS) function leading to radioiodine-...

The compounds derived from the oxidative stress and lipid peroxidation stimulate the bone loss, in part because they enhance the adipogenesis and blunt the osteoblastogenesis from mesenchymal stem cell (MSC), increasing the marrow adiposity that accompanies the osteoporosis. The consumption of omega-3 seems to have a protective effect on bone. This effect has been associated with the production of 15-hydroxy-eicosapentaenoic acid and 17-hydroxy-docosahexaenoic...

Case 1: Thirty-eight year woman consulted to gynecologist for oligomenorrhea in the last 4 years; PRL 51 μg/l and TSH 8.4 mU/l were discovered, initiating treatment with levotiroxine (f-T4). She got pregnant, persisting elevated levels of TSH and increasing f-T4, with normal campimetry. With the diagnostic of hyperthyroidism due to inadequate TSH secretion, treatment with PTU was initiated. After normal delivery, MRI showed a 22 mm. hypophisary macroadenoma and a transesp...

The mechanisms triggering autoimmunity in the Graves-Basedow disease (GBD) are unknown, although the evidence for a genetic predisposition is well established. The thyrotropin receptor (TSHR) is a good candidate gene.Objectives: To identify the main alleles/haplotypes of the TSHR gene, and to analyze the existence of TSHR susceptibility alleles to the GBD.Material and methods: To establish the main alleles of TSHR gene, 54 polymorp...